University of Lille 2, Inserm, France
Lead Contact: Dr Sebastien Bouret
The research group is affiliated with the Jean-Pierre Aubert Research Center (JPARC). This Research Center is affiliated with the Medical School of Lille (Université Lille 2, UL2) and Inserm (French National Institute of Health and Medical Research). More than 150 scientists and clinicians are involved in over 5 research teams in two main areas of research: Neuroscience (the PI's laboratory) and Cancer. The mission of the JPARC is to foster an environment of scientific excellence where biomedical research will lead to discoveries involving the molecular, cellular and clinical understanding of childhood and adult diseases. Institutional seminars are organized on a regular basis. The JPARC is well equipped for all aspects of the proposed studies. The PI's laboratory is equipped with dissecting microscopes, chemical hoods, and a fully equipped tissue culture room with BSL2 hood. The laboratory is also equipped with high-end fluorescent microscopes and devices for histological processing. Sufficient space for housing mice for the proposed studies is available in a state-of-the-art, pathogen free, animal facility in the Inserm building. Equipment for body composition (DEXA), hormone assay (Luminex multiplex system), small rodent imaging (7 Tesla MRI) studies and for carrying out surgical procedures in rodents (rats and mice) are also available. Free access is also provided to shared equipment (ultracentrifuges, DNA sequencing, real-time PCR). A state-of-the-art Zeiss LSM 710 confocal microscope is also available to the PI's laboratory in the imaging core facility of the JPARC.
Short profile of the staff members who will be undertaking the work:
Dr. Sebastien Bouret is a Neurobiologist with a strong background in developmental neuroendocrinology. He is also a leading expert in the field of metabolic programming and the developmental neurobiology of obesity. The major focus of Dr. Bouret's laboratory is to study the development of brain circuits that regulate appetite and energy balance. He is also interested in studying the influence of perinatal factors, such as hormones and nutrition, in the development of these critical pathways. He has published many articles, reviews, and book chapters in the field of developmental programming of obesity and has been invited to lecture internationally.
Dr. Vincent Prevot has received training in Neuroendocrinology from a number of excellent Institutions. He is well published and has considerable expertise in central actions of peripheral hormones, including a strong background in hormonal influences on CNS plasticity.