University of Koln Germany

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Lead contact: Professor Jens Bruning



The laboratory of Prof. Brüning is located in the Institute for Genetics, University of Cologne (Department for Mouse Genetics and Metabolism). The Institute for Genetics has a strong history in mouse genetics, particularly in the development of novel techniques for conditional mutagenesis. The Institute for Genetics has established the Center for Mouse Genetics (CMG), which is equipped with state-of-the-art facilities for the generation and maintenance of genetically modified mice. The transgenic service facility within the CMG is staffed with experienced personnel trained to perform the most advanced techniques for the manipulation of the mouse genome going far beyond those of standard mutagenesis.

In addition, the most advanced technology for metabolic characterization of mice, including complete assessment of energy homeostasis in mice as well as the availability of euglycemic, hyperinsulinemic clamps in mice for complete in vivo profiling of glucose metabolism in mutant mice is available. In the frame of the state-funded Excellence Cluster CECAD Cologne (Coordinator: Jens C. Brüning), several platforms have been established, among them a Mouse Phenotyping Platform providing equipment for behavior tests and phenomaster. Besides an existing NMR analyzer, a mouse CT is being purchased in the beginning of 2010.

Short profile of the staff members who will be undertaking the work:

Prof. Jens C. Brüning, MD, is Head of the Department for Mouse Genetics and Metabolism and coordinator of the state-funded Excellence Cluster CECAD Cologne. Prof. Brüning has an almost 15 year experience in the generation and characterization of mouse models with targeted disruption of insulin and leptin signaling components. More recently, his research has focused on the regulation of energy homeostasis through neuronal leptin, insulin receptors and cytokines. Research in his lab is currently funded by grants from DFG, BMBF, EU, and the Land NRW.

Bengt Belgardt, PhD, is highly experienced in analyses of energy homeostasis in the mouse and of signaling of various hormones in the brain.

Hella Brönneke, PhD, is head of the Mouse Phenotyping Platform within CECAD. She will provide support for the project in phenotypic investigation.

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