University of Edinburgh, UK
Joint Lead contacts: Professor Gareth Leng
Web Page: Professor Gareth Leng
Professor Mike Shipson
Web Page: Professor Mike Shipson
Gareth Leng is Professor of Experimental Physiology and Head of the School of Biomedical Sciences in the College of Medicine and Veterinary Medicine (CMVM). Mike Shipston is Professor of Physiology and Director of the Centre of Integrative Physiology, the largest of four research Centres within the School. Profs Leng and Shipston will jointly direct the Full4Health research programme at the University of Edinburgh.
The scientific remit of the Centre for Integrative Physiology (CIP) is to investigate key physiological mechanisms by determining the role of gene products in the integrated function of cells, organs and whole organisms. Investigators exploit appropriate model systems and focus on activities directly facilitating the understanding of human and mammalian physiology, development and disease. CIP investigators span the areas of genomics, proteomics, imaging, whole animal physiology and informatics. Their expertise embraces the cardiovascular, renal, reproductive, endocrine, nervous and immune systems and span a range of model organisms.
In the 2008 UK Research Assessment Exercise (RAE), the University of Edinburgh was confirmed as the leading research University in Scotland and one of the top five in the UK. The CMVM scored highly, particularly in Neuroscience (90 academic staff including Profs Leng and Shipston were included in the RAE Neuroscience submission). In 2009, research awards to CMVM exceeded £140M.
Short profile of the staff members who will be undertaking the work:
Prof Gareth Leng uses a multidisciplinary approach, including electrophysiology, molecular neuroanatomy, behavioural and functional studies, and computational modelling to understand the role of neural networks in the hypothalamus. His interests centre on the physiology of appetite and obesity.
Prof Mike Shipston uses electrophysiological and molecular biology techniques to examine post-transcriptional mechanisms of ion channel regulation and the impact of these mechanisms on the dynamic control of cellular excitability and systems level function.
Dr John Menzies is a postdoctoral fellow in the Centre for Integrative Physiology. He interested in the control of feeding and sexual behaviours by the hypothalamus, particularly the roles of neuropeptides like ghrelin, αMSH and oxytocin
Dr Nancy Sabatier holds a personal fellowship from Medical Research Scotland to study the role of the ventromedial hypothalamus and its responsiveness to peptides involved in appetite regulation.
Prof Mike Ludwig is Professor of Neurophysiology. He uses in vivo and in vitro approaches to understand the fundamental mechanisms of central dendritic peptide release in the hypothalamus and olfactory system and their role in feeding, social and sexual behaviours.