University of Cambridge, UK

University of Cambridge, UK

University of CambridgeLead contact: Dr Giles Yeo



Two independent research groups at UCAM (Institute of Metabolic Science (Giles Yeo) and Institute for Medical Research (Fiona Gribble) will contribute to the project. Both are part of the same legal entity:

The Metabolic Research Laboratories (MRL) are part of the Institute of Metabolic Science (IMS) within the University of Cambridge School of Clinical Medicine. The MRL undertakes basic and translational research relevant to the understanding, prevention and treatment of diabetes, obesity and other related endocrine and metabolic disorders.

Short profile of the staff members who will be undertaking the work:

Professor Stephen O'Rahilly is Head of the Department of Clinical Biochemistry, Director of the MRL and Director of the Medical Research Council Centre for Obesity and Related Metabolic diseases (MRC CORD). His group focuses on the study of patients with extreme phenotypes to understand the molecular mechanisms underlying severe obesity and insulin resistance.

Dr Giles Yeo is a Senior Research Associate and Director of Genomics and Transcriptomics in both the MRL and MRC CORD. His group uses genomics and transcriptomics techniques to study molecules and pathways in the hypothalamus that control food intake and body-weight. In more than 10 years working together, Prof O'Rahilly and Dr Yeo together with their close colleague, Dr Sadaf Farooqi, have identified five of the eight known monogenic causes of severe human obesity and helped establish the critical role of the leptin-melanocortin pathway in the control of food intake and bodyweight. More recently, Prof O'Rahilly and Dr Yeo have been using human genetics, rodent models and protein biochemistry to study the role of FTO, the first and most robust obesity 'polygene', in the control of energy homeostasis.

Other staff members involved

Anthony Coll - Senior Clinical Lecturer

Loraine Tung - Research Associate

Brian Lam - Research Associate

Pawan Gulati - Research Associate

Marcella Ma - Research Assistant

Marcella Cheung - PhD Student

Second UCAM research group


Drs Gribble and Reimann have a joint research laboratory in the Cambridge Institute for Medical Research (CIMR). CIMR provides extensive core facilities that include flow cytometry, confocal microscopy, cell culture, bioinformatics and quantitative RT-PCR analysis. Equipment in the Gribble/Reimann laboratory includes 5 dedicated electrophysiology and fluorescence imaging rigs, including facilities for dynamic FRET and TIRF microscopy. Five further post-docs and 2 PhD students in the Gribble/Reimann group will provide additional support and training to these projects. Clinical research is possible in the Clinical Research Facility, which is funded as part of the NIHR Biomedical Centre. This includes funding for supporting nursing staff to assist with clinical studies. The NIHR Biomedical Centre also includes a fully staffed Core Biochemical Assay Laboratory, providing low cost specialist metabolic assays such as gut peptides and insulin. MRC CORD provides fully staffed facilities for transcriptomic analysis and murine metabolic phenotyping.

Short profile of the staff members who will be undertaking the work:

Dr Fiona Gribble is a Wellcome Senior Research Fellow in Clinical Science and an Honorary Consultant in Diabetes and Related Metabolic Disorders, with 17 years of experience in basic and clinical research in the fields of diabetes in gut peptides. She is author of >60 original research articles, reviews and book chapters. Current interests are in the mechanisms of secretion and action of GLP-1 and related gut peptides.

Dr Frank Reimann is a Wellcome Senior Research Fellow in Basic Science, with >15 years of experience in research in biochemistry, molecular biology and biophysics. He has generated a number of transgenic mouse models for the study of enteroendocrine cells, including the fluorescently labelled K and L-cell models to be used in this project. His current interests include the secretion and action of GIP and other appetite and incretin-related gut peptides.

Dr Adrian Park is the Director of Obesity Services and a Consultant in Clinical Biochemistry, with >15 years research experience in the field of obesity and gut hormones.


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