University of Gothenburg

University of Gothenburg, The Sahlgrenska Academy at the University of Gothenburg, Sweden

University of GothenburgLead contact: Professor Suzanne Dickson

Email: Suzanne.Dickson@neuro.gu.se

Professor John-Olov Jansson

Email: joj@neuro.gu.se

Web: www.sahlgrenska.gu.se/english/

Two independent research groups at the UGOT, Sahlgrenska Academy, Institute of Neuroscience and Physiology, led by Suzanne Dickson and John-Olov Jansson, respectively will contribute to the project.

Suzanne L Dickson BSc PhD, Professor of Physiology/Neuroendocrinology; 20 years experience in research. Prior to her current appointment she held a tenured position as Senior Lecturer in the Dept Physiology at the University of Cambridge. She has around 70 publications in Peer Reviewed journals and has been an invited speaker at many International Congresses.


Short profile of the staff members who will be undertaking the work:

Suzanne L Dickson BSc PhD, Professor of Physiology/Neuroendocrinology; 20 years experience in research. Prior to her current appointment she held a tenured position as Senior Lecturer in the Dept Physiology at the University of Cambridge. She has around 50 publications in Peer Reviewed journals and has been an invited speaker at many International Congresses.

Senior post doctoral researchers:

Karolina Skibicka
PhD, Research area: role of the hindbrain in appetitive behaviour and feeding. Role: Principle scientist engaged in all tasks in WP10 and WP15. These include glucoprivation and appetitive behaviour.

Emil Egecioglu PhD, Research area: neurobiology of food reward. Role: to undertake many of the experiments of food intake, including CNS delivery of hormones.

Dr Mayte Alaverz will undertake neuroanatomical and miscroscopy work associated with the project. Caroline Hansson, a graduate student will prepare tissue for molecular analysis (to be done by UCAM).

The research group also benefits from an in house electrophysiologist, David Haage PhD.


Jansson UGOT research group

Professor John-Olov Jansson MD, PhD Prof Jansson is primarily interested in how immune factors such as cytokines affect hunger and body fat levels. These effects of immune factors are exerted in the brain, at the level of the hypothalamus and possibly also the brainstem. The first publications to convincingly show that an endogenous immune regulator can affect energy balance at the level of the brain was the finding by Wallenius et al (Nature Medicine 2002; 400 citations by March 2011 according to Web of Science) that knockout of the gene coding for the cytokine IL-6 causes mature onset obesity in healthy mice without overt inflammation. Similar findings were later reported by Jansson´s group and others for several immune factors such as IL-1 IL-18, GM-CSF, NFkB, JNK, and TNFα. There is now a growing body of evidence that the hunger-regulating regions of the brain are influenced from the gut, for instance by food composition and gut microbiota. A key collaboration for this project is with Dr Fredrik Bäckhed, a young scientist who is setting up a germ-free mouse facility in Gothenburg after spending a successful postdoc period in Jeff Gordon´s lab in St Louis, USA. A number of core facilities at the Sahlgrenska Academy will be used in the project, e.g. bio-imaging, genomics, and confocal microscopy. There is also ongoing collaboration with several immunologists at UGOT.


Short profile of the staff members who will be undertaking the work:

John-Olov Jansson, MD, PhD, Professor of Physiology/Neuroendocrinology; with 30 years experience of research and 5 years of clinical medicine.

Senior post doctoral researchers:

Louise Strandberg
PhD, Research area: interaction between immune system, body fat mass and nutrients. Role: to undertake many of the experiments on the effects of food composition on central immune factors, including cytokines, as well as other immune functions.

Erik Schéle, MSc, Ph D student will undertake neuroanatomical and microscope work as well as measurements of gene expression in the hypothalamus and brainstem associated with the project.

Hanna Asklund MSc, will together with Erik Schéle perform  neuroanatomical work in different parts of the hypothalamus.

Sara Svahn, MSc, MD-PhD  student that will participate in the studies of how food composition affects immune factors.


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